| Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment |
Chen Z.; Zhang C.; Shen H.; Xu H.; Huang Y.; Dong R.; Tang X.; Chai S.; Li J.; Xu J.; Zhang X.; Zhang Y.; Wu X.; Xu Y. |
2025 |
Acta pharmaceutica Sinica B |
| Dissecting the functional roles of CTCF and CTCF-s in human embryonic stem cells |
Hongxin Zhong, Yuli Lu, Jie Zhang, Gongcheng Hu, Guangjin Pan, Hongjie Yao |
2025 |
Journal of genetics and genomics |
| Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential |
Minjing Ke, Yuanyue Shan, Ziwei Zhai, Guoqiang Yao, Xinyi Guo, Xiaoxi Li, Zichao Wu, Huifeng Chen, Mengmeng Zhang, Meiyu Chen, Ying Li, Chengchen Zhao, Bo Wang, Micky D Tortorella, Xiaodong Shu, Mingfeng Zhang, Junqi Kuang, Duanqing Pei |
2025 |
NATURE COMMUNICATIONS |
| METTL3 and METTL14 determine human neural fate specifications |
Zhang Y.; Zhang J.; Lin H.; Wang J.; Chen Q.; Zhou T.; Xing Q.; Pan G.; Shan Y. |
2025 |
Nucleic Acids Research |
| Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts |
Deng M.; He D.; Wang X.; Yuan Y.; Wang L.; Hou Y.; Zhu Q.; Zhou C.; Mai Z.; Zhang Y.; Nie Z.; Song Y.; Wu Q.; Pan L.; Dong B.; Xiong Z.; Li D.; Liu D.; Xu J.; Qin D.; Zheng H.; Zhao Y.; Tang P.; Wang J.; Print C.; Jauch R.; Zhang W.; Wu G.; Bao X. |
2025 |
NATURE COMMUNICATIONS |
| Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development |
Zhihong Hao, Yi Wu, Yile Huang, Maolei Zhang, Yang Liu, Yueqiao Li, Wenxin Li, Zifeng Ruan, Jian Zhang, Yingzhe Ding, Linpeng Li, Guangsuo Xing, Zichao Liu, Yanshuang Zhou, Qi Wang, Keshi Chen, Wuming Wang, Gang Lu, Dajiang Qin, Wai-Yee Chan, Xingguo Liu |
2025 |
NATURE COMMUNICATIONS |
| Breaking the link between morphology and potency for mESCs |
Yixin Fan, Xiaomin Wang, Ziwei Zhai, Tao Huang, Wei Li, Zechuan Liang, Zhaoyi Ma, Yu Fu, Pengli Li, Junqi Kuang, Duanqing Pei |
2025 |
Cell and Bioscience |
| Polyomino reconstructs spatial transcriptomic profiles with single-cell resolution via a region-allocation method |
Quanyou Cai, Lihui Lin, Xin Liu, Jiekai Chen |
2025 |
Genome Research |
| UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions |
Xiang, Dan;Wu, Wenfeng; Shi, Ruona;Tang, Xiaoxiao; Zhang, Xiaofei |
2025 |
EMBO REPORTS |
| CD33KO-CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia |
Yao Wang, Xiujuan Zheng, Zhiqian Wang, Ziyun Xiao, Yunqing Lin, Fan Zhang, Yanhong Liu, Pengcheng Liu, Qitong Weng, Leqiang Zhang, Chengxiang Xia, Dehao Huang, Lijuan Liu, Yanping Zhu, Qi Zhang, Hanmeng Qi, Yi Chen, Yiyuan Shen, Chenyuan Zhang, Jiacheng Xu, Yaoqin Zhao, Jiaxin Wu, Tongjie Wang, Mengyun Zhang, Minming Li, Wenbin Qian 6 , Aibin Liang, Xin Du, Wenyu Yang, Tianyuan Hu, Qi Chen, Xiaofan Zhu, Fangxiao Hu, Jinyong Wang |
2025 |
Journal for ImmunoTherapy of Cancer |
| Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment |
Zhiming Chen, Cheng Zhang, Hui Shen, Hongrui Xu, Yumin Huang, Ruibo Dong, Xin Tang, Shuang Chai, Junhua Li , Jinxin Xu, Xiaohan Zhang, Yan Zhang, Xishan Wu, Yong Xu |
2025 |
Acta Pharmaceutica Sinica B |
| Gut microbiota remodeling exacerbates neuroinflammation and cognitive dysfunction via the microbiota-gut-brain axis in prenatal VPA-exposed C57BL/6 mice offspring |
Zhaoming Liu, Caixia Wu, Zhaojian Sun, Zuoxian Lin, Yirong Sun, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li |
2025 |
Frontiers in immunology |
| Spatiotemporal dynamics of neuron differentiation and migration in the developing human spinal cord |
Yuan Yu, Mengjie Pan, Quanyou Cai, Ziyu Feng, Baomei Cai, Kaixuan Lin, Shangtao Cao, Mingwei Min, Lihui Lin, Yanlin Ma, Jiekai Chen |
2025 |
Journal of genetics and genomics |
| RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53(R249S) Mutation and is a Potential Therapeutic Target |
Zhiping Wu, Zhe Wang, Diwei Zheng , Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P Thiery, Kwan Man, Peng Li |
2025 |
Advanced Science |
| Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia |
Hu, Jian-kang; Tang, Xin; Luo, Guo-long; Zhang, Cheng; Wu, Tian-bang; Wang, Chao; Shen, Hui; Zhao, Xiao-fan; Wu, Xi-shan; Smaill, Jeff B.; Xu, Yong; Zhang, Yan; Xiang, Qiu-ping |
2025 |
Acta pharmacologica Sinica |
| Artificial intelligence-enabled discovery of a RIPK3 inhibitor with neuroprotective effects in an acute glaucoma mouse model |
Xing Tu, Zixing Zou, Jiahui Li, Simiao Zeng, Zhengchao Luo, Gen Li, Yuanxu Gao, Kang Zhang |
2025 |
Chinese medical journal |
| Lhx2 specifically expressed in HSCs promotes liver regeneration and inhibits liver fibrosis |
Tao, Jiawang; Wu, Zichao; Liang, Yanran; Wang, Jiongliang; Tang, Miaoxiu; Huang, Sunan; Jiang, Fan; Zhou, Guangqi; Guo, Lin; Yuan, Shengxian; Li, Yinxiong; Wang, Jie |
2025 |
Hepatology |
| Triple-phase VPA administration in Sprague-Dawley rats: A cost-effective ASD model unveiling the synaptic-mitochondrial-inflammatory axis as a therapeutic target |
Zhaoming Liu, Caixia Wu , Zuoxian Lin, Heying Li , Yujie Liu, Nouman Amjad, Muhammad Majid, Rajesh Basnet, Zhiyuan Li
|
2025 |
Life sciences |
| Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria |
Yamin Gao, Cuiting Fang, Biao Zhou, H M Adnan Hameed, Changli Sun, Xirong Tian, Jing He, Xingli Han, Han Zhang, Jun Li, Jianhua Ju, Xinwen Chen, Nanshan Zhong,Junying Ma, Xiaoli Xiong,Tianyu Zhang |
2025 |
Communications biology |
| RNA modification is the mark and strategy for host-microbe interactions |
Ye Tian, Xiaoyun Wang |
2025 |
Cellular and molecular life sciences |
| Transcriptome-wide regulation of folate on neural mRNA m(6)A methylome via carbon metabolism in Drosophila and mammals |
Anrui Liu, Zhengyi Hu, Zihe Xu, Sisi Liu, Yuting Jiao, Rui Li, Yi Lu, Meng Yang, Jia Huang, Chen Huang, Xiaoyun Wang |
2025 |
Communications biology |
| High-resolution mapping of single cells in spatial context |
Jincan Ke, Jian Xu, Jia Liu, Yumeng Yang, Chenkai Guo, Bingbing Xie, Guizhong Cui, Guangdun Peng, Shengbao Suo
|
2025 |
Nature Communications |
| Structures and receptor binding activities of merbecovirus spike proteins reveal key signatures for human DPP4 adaptation |
Hang Yuan, Jingjing Wang , Yong Ma, Zimu Li, Xijie Gao, Gul Habib, Banghui Liu, Jing Chen, Jun He, Peng Zhou, Zheng-Li Shi, Xinwen Chen, Xiaoli Xiong
|
2025 |
Science Advances |
| ScReNI: Single-cell Regulatory Network Inference Through Integrating scRNA-seq and scATAC-seq Data |
Xueli Xu, Yanran Liang, Miaoxiu Tang, Jiongliang Wang, Xi Wang, Yixue Li , Jie Wang
|
2025 |
Genomics proteomics & bioinformatics |
| Copper ion-chelated supramolecular polymer/hyaluronic acid hydrogel promotes wound healing in diabetes |
Daoqiang Lu, Wenchong Yu , Danni Zhao, Fei Qi, Xiu Wang, Qiang Fu, Jie Li, Fang Yang, Riwang L, Xiaoxiao Wang, Haotian Lan, Jieyan Wang, Honglin Zhang, Dahai Liu, Jun Wang, Xiaodong Zhao
|
2025 |
International journal of biological macromolecules |
| Discovery of a Potent, Selective, and Multiple His435 Mutation-Sensitive Thyroid Hormone Receptor beta Agonist |
Qiu Li, Benqiang Yao, Shiting Zhao, Zhou Lu, Xishan Wu, Zhifang Lu, Tong Wu, Junhua Li, Xiaoshan Chen, Zhiming Chen, Cheng Zhang, Donghai Wu, Yan Zhang, Qiuping Xiang, Yong Li, Yong Xu
|
2025 |
Journal of medicinal chemistry |
| Reply: Considerations on the specific role of LHX2 in the process of hepatic stellate cells regulating hepatocyte function |
Jiawang Tao, Jie Wang
|
2025 |
Hepatology |
| Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer |
Lingyan Zhou, Feixiang Bao, Jiajun Zheng, Yingzhe Ding, Jiahui Xiao, Jian Zhang, Yongpeng Qin, Liang Yang , Yi Wu, Qi Meng, Manjiao Lu, Qi Long, Lingli Hu, Chong Li, Haitao Wang, Shijuan Huang, Linpeng Li, Junwei Wang, Wuming Wang, Gang Lu, Wai-Yee Chan, Dajiang Qin, Gong Chen, Xingguo Liu
|
2025 |
Molecular psychiatry |
| A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy |
Di Zhang, Jun Chen, Huaisong Lin, Min Zhou, Jinfei Hou, Wei Sun, Qi Xing, Wenhao Huang, Yanqi Zhang, Yiping Guo, Chunhua Liu, Aiping Lin, Cong Zhang, Yuhua Huang, Li-En Tao, Bowen Xie, Jian Zhang, Qianyu Chen, Yongli Shan, Yanling Zhu, Guangjin Pan, Lin-Ping Wu
|
2025 |
Journal of Advanced Research |
| Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase |
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng |
2025 |
Advanced science(Weinheim) |
